Twisted is pretty easy to build, since it is 99% pure python. There is one extension module that is compiled. It built fine with MSVC 2005.
I did some dumb hacking of course, since I don't know what I'm doing yet. I explicitly copies python25.lib to the twisted directory, set the paths right so cl.exe is in my path, and did python setup.py install. Good to go, or at least
>>> import twisted